منابع مشابه
Tranexamic acid in pediatric trauma: why not?
Trauma is a leading cause of death in pediatrics. Currently, no medical treatment exists to reduce mortality in the setting of pediatric trauma; however, this evidence does exist in adults. Bleeding and coagulopathy after trauma increases mortality in both adults and children. Clinical research has demonstrated a reduction in mortality with early use of tranexamic acid in adult trauma patients ...
متن کاملTranexamic acid and trauma-induced coagulopathy
Tranexamic acid (TXA) is a synthetic derivative of the amino acid lysine that inhibits fibrinolysis by blocking the interaction of plasminogen with the lysine residues of fibrin. Historically, TXA is commonly used for reduction of blood loss in perioperative situations, while recently it has attracted attention for clinical use in the trauma field. In 2010, the Clinical Randomization of an Anti...
متن کاملTrauma Pharmacology: Early Administration of Tranexamic Acid
Early hospital management of trauma patients is a daily activity for most emergency physicians. The ability to quickly assess, stabilize and initiate treatment of these patients is critically important to optimize outcomes. This issue of “Resident Journal Review” focuses on selected updates in the trauma literature. We specifically review new developments in trauma pharmacology, biomarkers in t...
متن کاملTranexamic acid administration to pediatric trauma patients in a combat setting: the pediatric trauma and tranexamic acid study (PED-TRAX).
BACKGROUND Early administration of tranexamic acid (TXA) has been associated with a reduction in mortality and blood product requirements in severely injured adults. It has also shown significantly reduced blood loss and transfusion requirements in major elective pediatric surgery, but no published data have examined the use of TXA in pediatric trauma. METHODS This is a retrospective review o...
متن کاملTranexamic acid in trauma: we need stronger global health policy.
José Caballero Alvarado Hospital Regional Docente de Trujillo, Peru, Yashbir Dewan MIND-Max Institute of Neurosciences Dehradun, India, Hesham Fathy Elsayed, Suez Canal University Hospital, Egypt, Tamar GogichaishviliHigh Technology Medical Centre, Georgia, Sanjay Gupta Fortis Hospital Delhi, India, B J Hunt Guy’s and St Thomas’ NHS Foundation Trust, UK, Pius Iribhogbe University of Benin Teach...
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ژورنال
عنوان ژورنال: Critical Care Clinics
سال: 2017
ISSN: 0749-0704
DOI: 10.1016/j.ccc.2016.08.004